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It is highly resistant to degradation in gastric fluid and has demonstrated a favorable safety profile in both experimental and clinical studies, including trials in inflammatory bowel disease in which no lethal dose was identified

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The presence of PN in PD subjects has been found to be associated with various factors in two large studies, including the total dosage of LDopa, low serum Vit B12 levels, and elevated Hcy and MMA levels (Ceravolo et al