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To elevate serotonin activity beyond the first-line serotonin reuptake inhibitor antidepressant effect, to treat depression patients responding inadequately, has been pursued from the 1970s (11, 28) till the present (29, 54) , by adjunctive (add-on) administration of a compound inducing Serotonin Synthesis Amplification: The optimal active compound to use in pharmaceutical technologies designed to produce Serotonin Synthesis Amplification is 5-hydroxytryptophan, 5-HTP

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