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Likewise, reestablished blood flow may certainly contribute to the rapid recovery effect noted, BPC 157 directly protects endothelium [47,56], alleviates the peripheral vascular occlusion disturbances [49,50,51,52,53,54,55,56,57,58,59,60], rapidly activating alternative bypassing pathway [49,50,51,52,53,54,55,56,57,58,59,60]

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Its design illustrates a radical peptidomimetic : only two amino acid residues (Tyr-Ile) are preserved from the native peptide, flanked by non-peptide acyl chains to cross biological barriers