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Administration of MPTP to mice lacking GSTpi also shows cellular ubiquitination and increased susceptibility to ubiquitin proteosome system (UPS) damage and inactivation [173]

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Conversely, deregulation of autophagy can accelerate cell damage and death, thereby contributing to pathological cascades, including endothelial dysfunction, vascular aging, and cardiovascular pathologies, including atherosclerosis and vascular calcification