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These early studies were quickly overshadowed by the subsequent discovery of the β-cell ATP-sensitive K + (K ATP ) channel (Cook and Hales, 1984), which provided a mechanism to explain how the plasma membrane responds to glucose metabolism and controls the timing of Ca 2+ influx and insulin secretion (Ashcroft et al., 1984

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Unlike resilient freeze-dried vials, pre-mixed peptide pens must be continuously maintained at a strict storage temperature of 2°C to 8°C