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[DOI] [PMC free article] [PubMed] [Google Scholar] [171].Bhatt PR, McNeely EB, Lin TE, Adams KF, Patterson JH, Review of Tolvaptan’s Pharmacokinetic and Pharmacodynamic Properties and Drug Interactions, J Clin Med, 3 (2014) 1276–1290

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Overall, mast cells have 50 – 200 granules in the cytoplasm of the cell, storing histamine, heparin, tryptase, cytokines, etc.[ref] The image below shows mast cell (stained purple) degranulation under a microscope.[ref] Allergies: Activating mast cells by Type 1 hypersensitivity In addition to reacting to antigens on pathogens, such as bacteria, the IgE can also be primed to link with antigens on proteins that are not pathogens, referred to as allergens