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As shown by our structure, complex formation of hTrxR1 with hTrx1 involves the generation of an intermolecular disulphide bond between the catalytic residues Cys32 hTrx1 and U498C′ hTrxR1 , which is supported by their neighbouring residues

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That figure came from an assay-specific in-vitro spine-density assay (picomolar Dihexa versus nanomolar BDNF) and does not mean Dihexa is millions of times more effective in a living brain