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Due to the targeted nature of the modifications, ME strictly depends on the a priori knowledge of the molecular and regulatory network underlying either the considered traits or produced metabolites

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Endothelial cells seeded on a three-dimensional matrix, such as Matrigel, are able to form capillary-like structure.34 HUVECs plated on Matrigel in limiting medium with increasing concentrations of BPC-157 formed more extensive tubes in a dose-dependent manner (Figure 5E–F)