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In 2010, Mazella and colleagues published in PLOS Biology that spadin, derived from the sortilin receptor, blocks a potassium channel called TREK-1

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Ruenzi et al., 2005) and in experimental rat studies (see Duzel et al., 2017), and has very safe profile (LD1 could be not achieved) (Seiwerth et al., 2018), a point recently confirmed (Xu et al., 2020)