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It has antioxidant effects, is a co-factor in mitochondrial energy metabolism, and contributes to DNA synthesis, the methylation cycle, and epigenetic regulation

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Moreover, direct inhibition of GPX4, whether via the use of the inhibitory molecule RAS-selective lethal (RSL3) or RNA interference (RNAi), also induces ferroptosis by allowing lipid peroxides to accumulate and damage cell membranes [25]