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This “hinge” occurs just N-terminal to a conserved HHxHx 2 Cx 2 C motif formally located in the C-terminal domain in the vicinity of the β2 and β3 strands (Figure 14B)

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Cyanocobalamin is a synthetic form of B₁₂ that contains a cyanide group, whereas hydroxocobalamin is a naturally occurring form produced by bacteria