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If HNC is diagnosed in the early developmental stages (I or II), a benign course of the pathology can reasonably be assumed

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LCA, DCA, and hyodeoxycholic acid (HDCA) suppress chemokines like CCL2 and CCL8, with LXRα activation implicated in this effect for DCA and HDCA ( In sum, BAs—especially those shaped by microbial metabolism—modulate macrophages through multiple nuclear and membrane receptors, balancing anti-inflammatory responses and pro-tumor M2 TAM expansion, underscoring their dual role in the TIME