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Vitamin B12 shot side effects Most people tolerate vitamin B12 injections well, but possible side effects include: Mild: soreness or redness at injection site, mild diarrhea, nausea, headache, itching Rare but serious: allergic reactions (rash, swelling, difficulty breathing), low potassium (hypokalemia), dizziness or heart rate changes Get emergency medical help if you have signs of an allergic reaction to Vitamin B12: hives

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[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Dalle-Donne I., Garavaglia M.L., Colombo G., Astori E., Lionetti M.C., La Porta C.A.M., Santucci A., Rossi R., Giustarini D., Milzani A