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The ER-localized E3 ubiquitin ligase membrane-associated ring-CH-type finger 6 (MARCHF6) may directly sense cytosolic NADPH levels via a unique C-terminal binding region, increasing the activity of this enzyme and resulting in changes in the levels of key regulators of ferroptosis, including acyl-CoA synthetase long-chain family member 4 (ACSL4) and p53 (ref