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Some studies reported alterations in gonadotropins and sex steroids following infection, including increased FSH and LH concentrations (111), reduced estradiol and LH levels (105), or broader endocrine abnormalities involving FSH, LH, estradiol, prolactin, and progesterone (105, 110)

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The combination of phase I and phase II metabolic reactions transforms the original lipophilic toxin into a more polar hydrophilic molecule