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it incorporates sophisticated mechanisms of microbial evolutionary adaptation and molecular mimicry ( Parallelly, invasive pathobionts exploit the structural blueprints of the host’s SLC25 family to subvert mucosal defenses ( In a fascinating counter-evolutionary response, host cells deploy localized “nutritional immunity” managed by the transport network ( To systematically elucidate these multidimensional interactions, Table 1 comprehensively summarizes the specific alterations of SLC25 family members across intestinal epithelial and diverse immune cell types, detailing their upstream triggers and profound impacts on IBD pathogenesis