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However, it has recently been found that Th1-like Treg cells, the dominant Treg cell subpopulation in RA, display low expression of TGF-β and defective inhibitory function ( Figure 4 Of note, cytotoxic CD8 + T cells are present in RA synovium, where they target citrullinated antigens and mediate joint tissue destruction ( + T is IL-17A + CD8 + T(Tc17) cells, similar with Th17 and CD8 + cells
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