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In a multicenter, randomized, placebo-controlled dose-finding trial, cagrilintide at doses ranging from 0.3 to 4.5 mg weekly produced dose-dependent weight reductions, with the 4.5 mg dose achieving approximately 10.8% weight loss at 26 weeks compared to 3.0% with placebo

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As a general rule of thumb, the larger the protein and the more complex folding it must undergo, the more likely it will accumulate in inclusion bodies