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Benefits (Research Focus) • Studied as a high-affinity potentiator of hepatocyte growth factor (HGF) signaling (Kd ≈ 65 pM) • Investigated for c-Met receptor activation and downstream signal transduction • Explored for functional dendritic spine formation and synaptic connectivity • Examined in rodent models of Alzheimer’s-like cognitive impairment • Researched as a structurally optimized angiotensin IV / AT4 receptor analog What Researchers Look At • HGF / c-Met receptor binding affinity and phosphorylation cascades • Dendritic spine density and synaptic protein expression in hippocampal cultures • Long-term potentiation (LTP) and electrophysiological endpoints in brain slice models • Cognitive performance in aged and AD-model rodents (Morris water maze, object recognition) • Comparative neurotrophic mimetic pharmacology versus BDNF and NGF Quick Specs • Form: Gelatin capsule • Strength: 5 mg / capsule • Quantity: 30 capsules per bottle • Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler • Purity: ≥99% • Storage: Store in a cool, dry, dark place Identity Basics • Compound: Dihexa • Synonyms: PNB-0408

Sodium Chloride 0.9%

Size:75g (Pack of 4)

[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Suzuki T, Nakamura A, Inukai M