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Strategies such as HDAC inhibition, astrocyte transplantation and modulation of autophagy or metabolic pathways remain confined to experimental models, whereas GLP-1 receptor agonists and MAO-B inhibitors have advanced to clinical testing and show effects on astrocytic metabolism and neuroinflammation

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Certain strains of intestinal bacteria are capable of producing histamine themselves by converting the amino acid histidine into histamine via an enzyme called histidine decarboxylase