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reported that all- trans retinoic acid (ATRA), which works via RXR, induced the expression of GS selectively (no effect on GCLC or GCLM) and GSH levels in myeloid-derived suppressor cells (Nefedova et al., 2007)

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To support this hypothesis, several studies claimed that autoreactive T cells specific for CII were not identified from either RA joints or the CIA model [44,45], which was further corroborated by another study using DR4 + CII peptide tetramer [46]