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Critical evidence deficiencies include insufficient high-quality, adequately powered randomized controlled trials, sparse long-term safety and effectiveness data, and minimal direct comparisons between treatment modalities

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Orally administered curcumin inhibited inflammatory cytokines such as TNF, cyclooxygenase (COX)-2, inducible nitric oxide synthase in mice indicating its anti-inflammatory activity and further suppressing dextran sodium sulfate-induced colon carcinogenesis [18]