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Mechanistically, inactivation of the CD73/adenosine A2A receptor (A2AR) signaling cascade accelerated the de novo synthesis and consumption of GSH with GSSG accumulation and concomitant mitochondrial lipid peroxidation, which linked potentially to PKA/E2F1–dependent fine-tuning of the ratio of GSR to GPX4

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[DOI] [PubMed] [Google Scholar] 8.Fletcher N.M., Saed M.G., Abu-Soud H.M., Al-Hendy A., Diamond M.P., Saed G.M