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Altogether, this research confirms that lowering the expression of PVT1 and miRNA-16-5p using SNHG1 may ameliorate the progression of OA by alleviating the ECM aberrant catabolism and inflammation, hence it is a promising therapeutic strategy against OA

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Patients should also be aware that folate supplementation should not be started before B12 deficiency has been treated, as doing so can precipitate or worsen neurological complications