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Musculoskeletal system Disorders associated with the musculoskeletal system often cause painful swelling and permanent damage in the joints of the body, especially the hips, knees and thumbs

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Neurotoxicity is apparently dose-dependent (frequent for 250–350 mg/m 2 , almost certain if dosage exceeds 500–600 mg/m 2 ) [102], although cases of early onset have been described, particularly in patients with neuropathy risk factors [103]