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For people with genetic variants that cause more of an impact on CYP1B1 upregulation – combined with an inability to eliminate the estrogen metabolites fast enough (due to phase II genes, diet, and lifestyle) – then cigarette smoking is going to significantly increase the ‘bad’ estrogen metabolites

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Once liver function normalizes, therapeutic paracetamol can be resumed, with the discontinuation of NAC guided by the toxicologist’s recommendation [28]