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GH = growth hormone, GHRH = growth hormone releasing hormone, IGF = insulin-like growth factor, PI3K = phosphoinositide 3-kinase, AKT = protein kinase B, mTOR = mammalian target of rapamycin, FoxO = forkhead box O, AOD = anti-obesity drug, AMPK = AMP-activated protein kinase

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Clopidogrel down-regulated the VEGF-A and VEGFR1 , subsequently inactivated AKT signaling pathway and induced phosphorylation of p38/MAPK and ERK/MAPK