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By attenuating NNMT activity, 5‑Amino‑1MQ has been observed in preclinical settings to elevate NAD+ availability, enhance metabolic flux, and upregulate downstream signaling programs associated with cellular stress responses and energy expenditure (e.g., SIRT1)

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[DOI] [PubMed] [Google Scholar] [87].Schnabel R, Lackner KJ, Rupprecht HJ, Espinola-Klein C, Torzewski M, Lubos E, Bickel C, Cambien F, Tiret L, Munzel T, Blankenberg S, Glutathione peroxidase-1 and homocysteine for cardiovascular risk prediction: results from the AtheroGene study