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Studies using oral doses of 500 mg per day showed only modest, variable increases in plasma glutathione levels across subjects, with the melanin index reduction measurable only under controlled spectrophotometric conditions after four weeks of consistent supplementation [1]

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The September approval was based on data from a Phase 3 clinical trial called JETALS (NCT03548311), in which Rozebalamin significantly slowed ALS disease progression when given alone or in combination with standard ALS treatments