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Within the airway epithelium, specifically in goblet and airway epithelial cells, the agonism of GLP-1 receptors results in reduced expression of IL-33 and thymic stromal lymphopoietin (TSLP), which subsequently suppress group 2 innate lymphoid cells (ILC2), Th2 cells, and eosinophils from releasing IL-4, IL-5, and IL-13, the so-called Th2-mediated cytokine profile

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