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NHS approach to B12 deficiency: NICE Clinical Knowledge Summaries recommend investigating B12 deficiency in patients presenting with macrocytic anaemia, unexplained neurological symptoms, or risk factors including pernicious anaemia, gastrectomy, malabsorption disorders, metformin use, proton pump inhibitors, or nitrous oxide exposure
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Two large genome-wide association studies found significant associations between PR3-AAV, but not MPO-AAV, and single nucleotide polymorphisms (SNPs) in the PR3 and AAT genes (156, 157)