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Consequently, we used both local and systemic applications (including via the per-oral way) [1,2,3,4,5,6,7,8,9,10]

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[4] However, consistently taking large amounts of vitamins from multiple sources could potentially increase the risk of side effects (for example, very high vitamin B₆ intake from multiple supplements over time can cause neuropathy, and high niacin from many sources could affect your liver)