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In the tumor tissues of liver cancer patients, larger mitochondria were observed, accompanied with raised expression of OPA1 and Mfn1, indicating enhanced mitochondrial fusion in tumor tissues, which promoted metabolism and tumor growth

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It was found that berberine reduced the expression of toll-like receptor 4 (TLR4), Src family tyrosine kinase (LYN), phatidylinositol 3-kinase (PI3K), NF-κB, TNF- α , IL-1, and caspase-3, which was accompanied by a reduction in cell apoptosis, which pointed to the potential significance of berberine in the therapy of PCOS (123)