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Cardiovascular disease, secondary prevention: Oral maintenance doses of L-carnitine 2 to 6 g/day for up to 12 months have been used in clinical studies

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In this paper, we present a new integrated model for hepatic glutathione metabolism including one-carbon metabolism and use it to investigate how the activation of certain enzymes by estradiol in one-carbon metabolism and glutathione metabolism leads to dramatic changes in reaction velocities and metabolite concentrations, including GSH and the GSH synthesis rate