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In a small study [43] with twelve healthy middle-aged non-smoker subjects taking either 500 or 1000 mg per day liposomal glutathione for four weeks, there was a trend towards increasing glutathione levels in a variety of body compartments, although it only became significant in plasma with the 500 mg dose after two weeks, which was also the largest increase at 25%

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The most common side effects include nausea, diarrhea, vomiting, constipation, stomach pain, headache, fatigue, dizziness, bloating, gas, and heartburn