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Melatonin production declines measurably after age 40, with some studies showing a 50% reduction in peak nocturnal melatonin by age 60 (Pandi-Perumal et al., Sleep Med Rev, 2006)

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Chronic hyperglycemia and insulin resistance: Increase oxidative stress Deplete glutathione Drive hepatic fat accumulation Elevated GGT frequently precedes the diagnosis of type 2 diabetes